Results | PROST

Summary

Q75VX8

Homolog: Q6PAJ3.
Function: GRB2-associated and regulator of MAPK protein 2.

Statistics

Total GO Annotation: 123
Unique PROST Go: 117
Unique BLAST Go: 0

Total Homologs: 23
Unique PROST Homologs: 17
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q6PAJ3 (GRB2-associated and regulator of MAPK protein 2) with a FATCAT P-Value: 1.12e-12 and RMSD of 4.16 angstrom. The sequence alignment identity is 87.1%.
Structural alignment shown in left. Query protein Q75VX8 colored as red in alignment, homolog Q6PAJ3 colored as blue. Query protein Q75VX8 is also shown in right top, homolog Q6PAJ3 showed in right bottom. They are colored based on secondary structures.

  Q75VX8 MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGVSERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPV 100
  Q6PAJ3 MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGVSERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPV 100

  Q75VX8 RYFSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEILCAKTTKERSRFTTLLRKLGRAGALAGVGGGGPASAGAAGG 200
  Q6PAJ3 RYFSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEILCAKTTKERSRFTTLLRKLGRAGALAGI--GGPGSMGATGG 198

  Q75VX8 TGGGGARPVKGKMPCLICMNHRTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRNPYDLHPVREGHCYKLVSIISKTVV 300
  Q6PAJ3 -GGGAARPVKSKMPCLICMNHRTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRNPYDLHPVREGHCYKLVSIISKTVV 297

  Q75VX8 LGLALRREGPAPLHFLLLTDTPRFALPQGLLAGDPRVERLVRDSASYCRERFDPDEYSTAVREAPAELAEDCASPRRARLCLPAPRAPGLARAPGP---L 397
  Q6PAJ3 LGLALRREGPAPLHFLLLTDTPRFTLPQGLLAGDPRVERLVRDSASYCRERFDPDEYSTAVREAPAELSDDCASPRHARLCLPAPRAPGAVRAPGPPGRL 397

  Q75VX8 APA-PA-GEGDQEYVSPDWAAAPEPAAPPAEIPYEELWAHQGPE----GLVRPPPGLDLISFGAAGPPRREPEAPPPPVPPKSEAVKEECRLLNAPPVPP 491
  Q6PAJ3 GPALPAPGDSDQDYVSPDWAGVSEPAGGCAEIPYEELWVHQAPESRADARARPLAGPDLISFGIVGPPRHEPEAPPPPVPPKSEAVKEECRLLHAPPVPP 497

  Q75VX8 RGGNGS-GRLSSSPPVPPRFPKLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDTYSLYCYPCTWGDCKVGESSSRPAPGPLPS-TTQPSQASRALTE 589
  Q6PAJ3 RGG-GSCSKLTGSPPVLPHFPKLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDAYSLYCYPCTWGDCKASESSSRPPPGPLPSTTTQPSQASRGLSE 596

  Q75VX8 PLSGRAASLLGADTP-VKTYHSCPPLFKPSHPQKRFAPFGALNPFSGPAYPSG-PSAALSSGPRTTSGPVATSGPAYSPGPA-SP-GQAYSAAPPSSCAP 685
  Q6PAJ3 PLSGRTPSLLGADTPVVKNYHSCPPLFKSSRPQKSFAPFGALNPFSGPAHPSGAPAAS-SSGSISTSGVLATSSPTHSPGPGPGPQGQGYSA------AP 689

  Q75VX8 SSS-SSSEWQEPVLEPFDPFELGQGSSPEPELLRSQEPRAVGTPGPGPRLSPLGPSKAFEPEGLVLHQVPTPLSPAALQGPEAGGA-LFLTQGRLEGPPA 783
  Q6PAJ3 SSSLSSSEWQEPALEPLDPFELGQASPPELELVRCQEPRAAGAPGSGPCLSPLGQPKAFEPEGLVLRQVPASLSPAALQGPEAGGTLLFLTQGCLEGPPG 789

  Q75VX8 SPRDGATGFGVRDASSWQPPADLSALSLEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILADDFHLTKLQVKKIMQFIKGWRPKI 874
  Q6PAJ3 SPREGATGAGVRDASSWQPPADLSALSLEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILADDFHLTKLQVKKIMQFIKGWRPKI 880

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.

Show entries

Search:

Source	GO	Description
1. PB	GO:0051781	positive regulation of cell division
1. PB	GO:0070374	positive regulation of ERK1 and ERK2 cascade
1. PB	GO:0071364	cellular response to epidermal growth factor stimulus
1. PB	GO:0070064	proline-rich region binding
1. PB	GO:0007173	epidermal growth factor receptor signaling pathway
1. PB	GO:0008284	positive regulation of cell population proliferation
2. P	GO:0050680	negative regulation of epithelial cell proliferation
2. P	GO:0005159	insulin-like growth factor receptor binding
2. P	GO:0016055	Wnt signaling pathway
2. P	GO:0010718	positive regulation of epithelial to mesenchymal transition

Showing 1 to 10 of 123 entries

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Show entries

Search:

Source	Homolog	Description	FATCAT p-val	PROST Evalue	BLAST Evalue
1. PB	Q75VX8	GRB2-associated and regulator of MAPK protein 2	0	1.05e-135	0.0
1. PB	Q6NRE4	GRB2-associated and regulator of MAPK protein	3.80e-07	2.30e-47	0.0
1. PB	Q7ZVU1	GRB2-associated and regulator of MAPK protein 1	9.66e-09	3.26e-41	4.92e-164
1. PB	Q3UFT3	GRB2-associated and regulator of MAPK protein	9.45e-03	2.19e-54	0.0
1. PB	Q9H706	GRB2-associated and regulator of MAPK protein 1	3.92e-07	4.23e-53	0.0
1. PB	Q6PAJ3	GRB2-associated and regulator of MAPK protein 2	1.12e-12	2.12e-81	0.0
2. P	Q6P4Y6	Insulin receptor substrate 1	3.16e-01	7.83e-04	NA
2. P	Q5DTW2	Scm-like with four MBT domains protein 2	5.53e-01	9.09e-03	NA
2. P	Q9UQR0	Sex comb on midleg-like protein 2	3.55e-01	3.01e-02	NA
2. P	O88797	Disabled homolog 2	3.73e-01	3.99e-02	NA

Showing 1 to 10 of 23 entries