Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q6P1S6
(Myotrophin) with a FATCAT P-Value: 8.22e-15 and RMSD of 1.45 angstrom. The sequence alignment identity is 16.0%.
Structural alignment shown in left. Query protein B4E2M5 colored as red in alignment, homolog Q6P1S6 colored as blue.
Query protein B4E2M5 is also shown in right top, homolog Q6P1S6 showed in right bottom. They are colored based on secondary structures.
B4E2M5 MDTTLRMVRTACQHRAPQISHKTGCSHISMHSPGGLTTTKMAGPLPRVSDSLFSAMELAKMSDMTK-LHQAVAAGDYSLVKK-ILKKGLCDPNYKDVDWN 98 Q6P1S6 ------------------------------------------------------------MGD--KEFVWAIKNGDLDAVKEFVL--GGEDVN-RTLD-G 34 B4E2M5 DRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSV---GWTPAHFAAEAGHLNILKTLHALHAAID----APDFFGDTPKRIAQIYGQKACVAFLEKAEPEC 191 Q6P1S6 GRKPMHYAADCGQDEVLEFLLSKGAN---INAADKHGITPLLSACYEGHRKCVELL--LSKGADKTVKGPD-------------GLNA----LESTDNQA 112 B4E2M5 -QD--HRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMNKKNKKSRGPTRPSNTKGRRV 251 Q6P1S6 IKDLLH--------------------------------------------------------- 118
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PB | GO:0051489 | regulation of filopodium assembly |
| 1. PB | GO:0001938 | positive regulation of endothelial cell proliferation |
| 1. PB | GO:0000082 | G1/S transition of mitotic cell cycle |
| 1. PB | GO:2000346 | negative regulation of hepatocyte proliferation |
| 1. PB | GO:0090398 | cellular senescence |
| 1. PB | GO:0061630 | ubiquitin protein ligase activity |
| 1. PB | GO:0090399 | replicative senescence |
| 1. PB | GO:0034587 | piRNA metabolic process |
| 1. PB | GO:0032695 | negative regulation of interleukin-12 production |
| 1. PB | GO:0030154 | cell differentiation |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | A6NGH8 | Ankyrin repeat domain-containing protein 61 | 1.68e-05 | 7.40e-03 | 0.006 |
| 1. PB | Q2IBB4 | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 | 1.10e-04 | 4.98e-02 | 0.006 |
| 1. PB | Q6KAE5 | Probable E3 ubiquitin-protein ligase XBOS32 | 1.15e-04 | 1.89e-04 | 7.27e-05 |
| 1. PB | Q8N9B4 | Ankyrin repeat domain-containing protein 42 | 3.01e-05 | 1.24e-05 | 2.35e-08 |
| 1. PB | Q8N9V6 | Ankyrin repeat domain-containing protein 53 | 2.16e-05 | 4.12e-02 | 4.31e-05 |
| 1. PB | P14360 | Putative ankyrin repeat protein FPV240 | NA | 9.80e-04 | 2.88e-07 |
| 1. PB | Q8VHQ3 | Protein phosphatase 1 regulatory inhibitor subunit 16B | 7.20e-04 | 4.09e-05 | 2.70e-05 |
| 1. PB | P51480 | Cyclin-dependent kinase inhibitor 2A | 1.81e-07 | 1.04e-07 | 3.22e-05 |
| 1. PB | Q9J504 | Putative ankyrin repeat protein FPV231 | NA | 4.20e-03 | 0.044 |
| 1. PB | Q91ZT9 | Ankyrin repeat and SOCS box protein 8 | 7.18e-07 | 3.75e-06 | 4.81e-07 |