Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PB was
Q8BXX9
(Coiled-coil domain-containing protein 169) with a FATCAT P-Value: 5.66e-15 and RMSD of 3.29 angstrom. The sequence alignment identity is 71.0%.
Structural alignment shown in left. Query protein A6NNP5 colored as red in alignment, homolog Q8BXX9 colored as blue.
Query protein A6NNP5 is also shown in right top, homolog Q8BXX9 showed in right bottom. They are colored based on secondary structures.
A6NNP5 MKEERNYNFDGVSTNRLKQQLLEEVRKKDAVQLSIFELRHKITELEAKLNTDNEGSEWKTRYETQLELNDELEKQIVYLKEKVEKIHGNSSDRLSSIRVY 100 Q8BXX9 MGEGHGDTFEGVSTDRLKLELLEEIHMKDVVQLSTLEIRHKIAELEANLNGDLAGSEWKTRYETQLELNDQLEKQIVSLKEKMEKMRGNPSDRLSSIRVY 100 A6NNP5 ERMPVESLNTLLKQLEEEKKTLESQVKYYALKLEQESKAYQKINNERRTYLAEMSQGSGLHQVSKRQQVDQLPRMQENLVKTGRYNPAKQKTVSAKRGPV 200 Q8BXX9 EKMPVESLNVLLKQLEKEKRSLESQVKEYAFRLEQESKAYHRTNNERRSYIAEMTQVSGSNQVSKRQQMDPLPRMKESPVKTGRHNSMNQKTTNAKKGPV 200 A6NNP5 KKITRPNHLPELHP 214 Q8BXX9 KKVPRSNHLPKLNP 214
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 2. P | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway |
| 2. P | GO:0008090 | retrograde axonal transport |
| 2. P | GO:0070530 | K63-linked polyubiquitin modification-dependent protein binding |
| 2. P | GO:1901970 | positive regulation of mitotic sister chromatid separation |
| 2. P | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| 2. P | GO:0051081 | nuclear membrane disassembly |
| 2. P | GO:0051028 | mRNA transport |
| 2. P | GO:0019904 | protein domain specific binding |
| 2. P | GO:0007080 | mitotic metaphase plate congression |
| 2. P | GO:0005881 | cytoplasmic microtubule |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q3KPT0 | Coiled-coil domain-containing protein 169 | 2.06e-10 | 1.27e-41 | 1.55e-54 |
| 1. PB | A6NNP5 | Coiled-coil domain-containing protein 169 | 0 | 9.71e-167 | 1.84e-155 |
| 1. PB | Q8BXX9 | Coiled-coil domain-containing protein 169 | 5.66e-15 | 5.16e-63 | 6.60e-105 |
| 2. P | Q5U465 | Coiled-coil domain-containing protein 125 | 3.45e-05 | 1.55e-02 | NA |
| 2. P | Q66IZ7 | Nuclear distribution protein nudE-like 1-B | 1.12e-07 | 5.63e-07 | NA |
| 2. P | Q6QZQ4 | Vimentin-type intermediate filament-associated coiled-coil protein | 3.86e-06 | 1.58e-02 | NA |
| 2. P | F4I878 | Protein BRANCHLESS TRICHOME | 1.63e-06 | 9.42e-06 | NA |
| 2. P | Q5ZMC9 | Nuclear distribution protein nudE homolog 1 | 1.45e-07 | 4.94e-04 | NA |
| 2. P | O76878 | RILP-like protein homolog | 3.83e-05 | 5.22e-06 | NA |
| 2. P | C7GY13 | SWI5-dependent HO expression protein 3 | 1.05e-05 | 4.23e-06 | NA |